Melittin, TFA Salt

Apitherapy (the use of honey bee products in alternative medicine) is an emerging field, with a long history of unsupported health benefits, particularly in cancer. Components of bee venom have been demonstrated to have anti-tumoral effects in various cancers. For example, honey bee venom was shown to reduce metastases of breast cancer to the lungs and inhibit tumor growth (Orsolić, et al., 2003). Similarly, the active component of bee venom, a peptide called melittin, showed anticancer selectivity through undefined molecular mechanisms and suggests novel treatment strategies for aggressive breast cancers (Duffy, et al., 2020).||Sequence:|GIGAVLKVLTTGLPALISWIKRKRQQ|(Modification: Gln-26 = C-terminal amide)||Synonyms:|Bee Venom Powder||CAS No:|Free Base: 20449-79-0||Molecular Formula:|C131H229N39O31||Molecular Weight:|2960.48||Appearance:|White to off-white powder||Purity:|≥99%||1H-NMR:|Conforms to reference||Solubility:|Water: 50mg/ml||Storage and Stability:|Store at 4°C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.