Interleukin 15, Recombinant, Human (Interleukin-15, IL-15, IL15)

IL-15 is an immunomodulating cytokine that stimulates the proliferation of T lymphocytes and shares many biological properties with IL-2. IL-15 exerts its biological activities primarily on T cells. It is also essential in the development, survival and activation of NK cells. Increased expression of IL-15 has been linked to rheumatoid arthritis, inflammatory bowel disease, and diseases affiliated with retroviruses HIV and HTLV-I. Human IL-15 is biologically active on mouse cells as measured by the dose-dependent stimulation of the proliferation of mouse CTLL cells. Recombinant Human IL-15 is a 12.9kD protein consisting of 115 amino acid residues.||Recombinant protein corresponding to human IL-15, expressed in E. coli. Uniprot/Swiss Accession: P40933||Molecular Weight: |~12.9kD (115aa sequence) ||Biological Activity:|Determined by its ability to stimulate the proliferation of mouse CTLL-2 cells. The expected ED50 is ≤0.5ng/ml, corresponding to a specific activity of >2x10e6units/mg.||Amino Acid Sequence:|MNWVNVISDL KKIEDLIQSM HIDATLYTES DVHPSCKVTA|MKCFLLELQV ISLESGDASI HDTVENLIIL ANNSLSSNGN|VTESGCKECE ELEEKNIKEF LQSFVHIVQM FINTS||Applications:|Suitable for use in Functional Assays. Other applications not tested. ||Recommended Dilution:|Optimal dilutions to be determined by the researcher. ||Storage and Stability:|Lyophilized and reconstituted products are stable for 6 months after receipt at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.