Anti-HLA-DRA antibody (Clone: L243) {PerCP/Cyanine5.5}

Clonality:	Monoclonal
Clone ID:	L243
Conjugation:	PerCP/Cyanine5.5
Isotype:	IgG2ak
Formulation:	PBS with 0.05% Proclin300, 1% BSA
Storage Instruction:	Recommend storing between 2-8°C and protecting from prolonged exposure to light. Do not freeze this product.

Gene Symbol:	HLA-DRA
Gene ID:	3122
Uniprot ID:	DRA_HUMAN

Tissue Specificity	Expressed in professional APCs: macrophages, dendritic cells and B cells (at protein level). Expressed in thymic epithelial cells (at protein level).
Post Translational Modifications	Ubiquitinated by MARCHF1 or MARCHF8 at Lys-244 leading to down-regulation of MHCII. When associated with ubiquitination of the beta chain at 'Lys-254', the down-regulation of MHCII may be highly effective.
Function	An alpha chain of antigen-presenting major histocompatibility complex class II (MHCII) molecule. In complex with the beta chain HLA-DRB, displays antigenic peptides on professional antigen presenting cells (APCs) for recognition by alpha-beta T cell receptor (TCR) on HLA-DR-restricted CD4-positive T cells. This guides antigen-specific T-helper effector functions, both antibody-mediated immune response and macrophage activation, to ultimately eliminate the infectious agents and transformed cells. Typically presents extracellular peptide antigens of 10 to 30 amino acids that arise from proteolysis of endocytosed antigens in lysosomes. In the tumor microenvironment, presents antigenic peptides that are primarily generated in tumor-resident APCs likely via phagocytosis of apoptotic tumor cells or macropinocytosis of secreted tumor proteins. Presents peptides derived from intracellular proteins that are trapped in autolysosomes after macroautophagy, a mechanism especially relevant for T cell selection in the thymus and central immune tolerance. The selection of the immunodominant epitopes follows two processing modes: 'bind first, cut/trim later' for pathogen-derived antigenic peptides and 'cut first, bind later' for autoantigens/self-peptides. The anchor residue at position 1 of the peptide N-terminus, usually a large hydrophobic residue, is essential for high affinity interaction with MHCII molecules.
Protein Name	Hla Class Ii Histocompatibility Antigen - Dr Alpha Chain Mhc Class Ii Antigen Dra
Database Links	Reactome: R-HSA-202424 Reactome: R-HSA-202427 Reactome: R-HSA-202430 Reactome: R-HSA-202433 Reactome: R-HSA-2132295 Reactome: R-HSA-389948 Reactome: R-HSA-877300
Cellular Localisation	Cell Membrane Single-Pass Type I Membrane Protein Endoplasmic Reticulum Membrane Early Endosome Membrane Late Endosome Membrane Lysosome Membrane Autolysosome Membrane The Mhcii Complex Transits Through A Number Of Intracellular Compartments In The Endocytic Pathway Until It Reaches The Cell Membrane For Antigen Presentation Component Of Immunological Synapses At The Interface Between T Cell And Apc
Alternative Antibody Names	Anti-Hla Class Ii Histocompatibility Antigen - Dr Alpha Chain antibody Anti-Mhc Class Ii Antigen Dra antibody Anti-HLA-DRA antibody Anti-HLA-DRA1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance