Anti-GZMB antibody (50-100) {Biotin}

Clonality:	Polyclonal
Conjugation:	Biotin
Isotype:	IgG
Purification:	Affinity Purified
Concentration:	0.63 µg/µl
Dilution Range:	WB: 1:500 DB: 1:10, 000 ELISA: 1:10, 000 IP: 1:150 IHC: 1:50-1:100
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	GZMB
Gene ID:	3002
Uniprot ID:	GRAB_HUMAN
Immunogen Region:	50-100
Immunogen:	Synthetic peptide taken within amino acid region 50-100 on human endogenous Granzyme B protein.

Function	Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent pyroptosis when delivered into the target cell through the immunological synapse. It cleaves after Asp. Once delivered into the target cell, acts by catalyzing cleavage of gasdermin-E (GSDME), releasing the pore-forming moiety of GSDME, thereby triggering pyroptosis and target cell death. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -9 and -10 (CASP3, CASP9 and CASP10, respectively) to give rise to active enzymes mediating apoptosis. Cleaves and activates CASP7 in response to bacterial infection, promoting plasma membrane repair.
Protein Name	Granzyme B C11 Ctla-1 Cathepsin G-Like 1 Ctsgl1 Cytotoxic T-Lymphocyte Proteinase 2 Lymphocyte Protease Fragmentin-2 Granzyme-2 Human Lymphocyte Protein Hlp Sect T-Cell Serine Protease 1-3e
Database Links	Reactome: R-HSA-2197563 Reactome: R-HSA-5620971 Reactome: R-HSA-75108
Cellular Localisation	Secreted Cytolytic Granule Delivered Into The Target Cell By Perforin
Alternative Antibody Names	Anti-Granzyme B antibody Anti-C11 antibody Anti-Ctla-1 antibody Anti-Cathepsin G-Like 1 antibody Anti-Ctsgl1 antibody Anti-Cytotoxic T-Lymphocyte Proteinase 2 antibody Anti-Lymphocyte Protease antibody Anti-Fragmentin-2 antibody Anti-Granzyme-2 antibody Anti-Human Lymphocyte Protein antibody Anti-Hlp antibody Anti-Sect antibody Anti-T-Cell Serine Protease 1-3e antibody Anti-GZMB antibody Anti-CGL1 antibody Anti-CSPB antibody Anti-CTLA1 antibody Anti-GRB antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance