TARGATT™ Fast and Site-Specific shRNA Knock-down Mice Service

Gene knock-out technology using short hairpin RNA (shRNA) to inhibit expression of the corresponding gene has been widely used in gene function studies, drug discovery, and disease research.
Our TARGATT™ technology allows you to generate an in vivo shRNA Knock-down Mouse model in as little as 3 months.

To generate your TARGATT™ shRNA Mouse, you will need a TARGATT™ Kit (AST#) to prepare the DNA and a TARGATT™ mouse colony (AST#) for pronuclear injection. All steps are also available as individual service options.

Features of TARGATT™ shRNA Knock-down:

• shRNA copy number is controlled

• Specific locus insertion guarantees the expression of shRNA

• shRNA expression can be regulated by a tissue-specific promoter

• Founder mice can be generated in as little as 3 months

• Full service including shRNA design, construction, and validation is available