TJP1 Human siRNA Oligo Duplex (Locus ID 7082)

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Cat# SR322042

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TJP1 Human siRNA Oligo Duplex (Locus ID 7082)

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SR322042

TJP1 (Human) - 3 unique 27mer siRNA duplexes - 2 nmol each

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Stability One year from date of shipment when stored at -20°C. # of transfections Approximately 330 transfections/2nmol in 24-well plate under optimized conditions (final conc. 10 nM). Note Single siRNA duplex (10nmol) can be ordered. Reference Data RefSeq NM_001301025, NM_001301026, NM_003257, NM_175610, NM_001330239, NM_001355012, NM_001355013, NM_001355014, NM_001355015 UniProt ID Q07157 Synonyms ZO-1 Summary This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family of proteins, and acts as a tight junction adaptor protein that also regulates adherens junctions. Tight junctions regulate the movement of ions and macromolecules between endothelial and epithelial cells. The multidomain structure of this scaffold protein, including a postsynaptic density 95/disc-large/zona occludens (PDZ) domain, a Src homology (SH3) domain, a guanylate kinase (GuK) domain and unique (U) motifs all help to co-ordinate binding of transmembrane proteins, cytosolic proteins, and F-actin, which are required for tight junction function. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017] Performance Guaranteed OriGene guarantees that at least two of the three Dicer-Substrate duplexes in the kit will provide at least 70% or more knockdown of the target mRNA when used at 10 nM concentration by quantitative RT-PCR when the TYE-563 fluorescent transfection control duplex (cat# SR30002) indicates that >90% of the cells have been transfected and the HPRT positive control (cat# SR30003) provides 90% knockdown efficiency.

For non-conforming siRNA, requests for replacement product must be made within ninety (90) days from the date of delivery of the siRNA kit. To arrange for a free replacement with newly designed duplexes, please contact Technical Services at tech@biovalley.fr. Please provide your data indicating the transfection efficiency and measurement of gene expression knockdown compared to the scrambled siRNA control (quantitative RT-PCR data required).