ELISA: Dilute the antibody approx. 1:300,000 for detection of Kchip1 peptide (QTKQRRPSKDK) coated on ELISA plate. Western blot: Dilute approx. 1:4,000 to detect the 27kDa Kchip1 in mouse brain extract.
Reactivity
Mouse
Antibody Host
Rabbit
Clonality
Polyclonal
Immunogen
A synthetic peptide derived from the amino sequence amino acid 12-22 of mouse Kchip1, conjugated with KLH
Specificity
This antibody is reactive to the 27kDa Kchip1 in Mouse and other species with consensus Kchip1 sequence.
Restore with double distilled water to adjust the final concentration to 1.00 mg/ml.
Purification
Protein G affinity
Conjugation
Unconjugated
Storage
Store lyophilized at 2-8°C for 6 month or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing.
KChIP1 is an important member of the potassium channel interacting protein family. It binds to and influences the voltage gated potassium (Kv) channel. Like all other members in the family, KChIP1 has calcium binding domains (EF-hand-like) that sense calcium concentrations to regulate Kv channel. KChIP1 frequently forms complex with the rapid inactivating A-type Kv channels. It may play a role in modulating somatodendritic excitability, and the repolarization of cardiac myocytes following action potential. It is also reported that KChIP1 is associated with the GABAergic synapses in hippocampus.
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