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> IL 18 Protein

IL 18 Protein

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Cat# OPPA00534

Size : 5ug

Brand : Aviva Systems Biology

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Datasheets/ManualsPrintable datasheet for OPPA00534
Product Info
Predicted Species ReactivityHuman
Product FormatLyophilized 0.5x PBS (pH 7.3)
HostE. Coli
Reconstitution and StorageIt is recommended to reconstitute the lyophilized Interleukin 18 in sterile 18M-omega-cm H2O not less than 100 ug/mL, which can then be further diluted to other aqueous solutions. Lyophilized Interleukin 18 although stable at room temperature for 3 weeks, should be stored dessicated below -18°C. Upon reconstitution IL18 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage, it is recommended to add a carrier protein (0.1% HSA and BSA). Please prevent freeze/thaw cycles.
PurificationPurified by proprietary chromatographic techniques.
Concentration1 mg/ml (prior to lyophilization)
PurityGreater than 98.0% as determined by (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Biological ActivityThe ED50 as determined by the dose-dependant stimulation of the IFN-g by human PBMC co-stimulated with IL-12 was found to be 5 ng/ml corresponding to a Specific Activity of 200,000 IU/mg.
Gene SymbolIL18
Alias SymbolsIGIF, IL-18, IL-1g, IL1F4
NCBI Gene Id3606
Protein NameInterleukin-18
Description of TargetIL-18 is a proinflammatory cytokine. This cytokine can induce the IFN-gamma production of T cells. The combination of this cytokine and IL12 has been shown to inhibit IL4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL-18 binding protein (IL18BP) can specifically interact with this cytokine, and thus negatively regulate its biological activity. Interleukin-18 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 157 amino acids.
Uniprot IDQ14116
Protein Accession #NP_001553.1
Protein Size (# AA)Recombinant
Molecular Weight18 kDa
Protein interactions
Name# of Products
CASP198
CASP3324
CASP479
IL18BP5
IL18R115
IL18RAP14
IL1RL25
Biological pathways
Name# of Products
Angiogenesis366
Cell-cell signaling763
Chemokine biosynthetic process5
Granulocyte macrophage colony-stimulating factor biosynthetic process5
Interferon-gamma biosynthetic process23
Interleukin-13 biosynthetic process6
Interleukin-2 biosynthetic process5
Positive regulation of activated T cell proliferation123
Positive regulation of granulocyte macrophage colony-stimulating factor production23
Positive regulation of inflammatory response172
Positive regulation of interferon-gamma production108
Positive regulation of interleukin-17 production72
Positive regulation of natural killer cell proliferation23
Positive regulation of NK T cell proliferation16
Positive regulation of tissue remodeling50
Regulation of cell adhesion64
Sleep11
T-helper 1 type immune response37
Type 2 immune response21
Biological process
Name# of Products
Angiogenesis196
Cell-cell signaling235
Cellular response to cAMP28
Cellular response to hydrogen peroxide38
Cellular response to interferon-gamma26
Cellular response to mechanical stimulus62
Cellular response to organic cyclic compound58
Cellular response to parathyroid hormone stimulus6
Cellular response to peptide hormone stimulus16
Cellular response to tumor necrosis factor39
Chemokine biosynthetic process1
Detection of mechanical stimulus involved in sensory perception of pain7
Digestive tract morphogenesis23
Granulocyte macrophage colony-stimulating factor biosynthetic process1
Immune response404
Inflammatory response339
Interferon-gamma biosynthetic process8
Interleukin-13 biosynthetic process2
Interleukin-2 biosynthetic process2
Lipopolysaccharide-mediated signaling pathway48
Lung development105
MAPK cascade105
Osteoblast differentiation57
Positive regulation of activated T cell proliferation45
Positive regulation of chemokine production34
Positive regulation of collagen biosynthetic process29
Positive regulation of gene expression160
Positive regulation of granulocyte macrophage colony-stimulating factor production13
Positive regulation of inflammatory response57
Positive regulation of interferon-gamma production61
Positive regulation of interleukin-1 beta production6
Positive regulation of interleukin-17 production27
Positive regulation of interleukin-8 production33
Positive regulation of male germ cell proliferation3
Positive regulation of natural killer cell proliferation14
Positive regulation of neuron apoptosis53
Positive regulation of NK T cell proliferation8
Positive regulation of superoxide anion generation6
Positive regulation of tissue remodeling6
Positive regulation of tumor necrosis factor production64
Positive regulation of vascular permeability16
Regulation of blood vessel remodeling3
Regulation of cell adhesion41
Response to cold31
Response to hyperoxia20
Response to hypoxia205
Response to radiation32
Sleep21
T-helper 1 type immune response14
Type 2 immune response3
Cellular components
Name# of Products
Apical plasma membrane173
Cytoplasm4549
Cytosol1868
Extracellular region1573
Extracellular space884
Protein function
Name# of Products
Cytokine activity1104

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