General Info
Applications: | ELISA |
Reactivity: | Human |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Sensitivity: | 0.39 pg/mL |
Detection Limit: | 078-50 pg/ml |
Short Description: | This IL2 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
Conjugation: | Biotin |
Storage Instruction: | Unopened kits can be stored at 2-8°C for 1 year, and opened products must be used within 1 month. |
Assay Time: | 4 hours |
Detection: | Colorimetric |
Information
Gene Symbol: | IL2 |
Gene ID: | 3558 |
Uniprot ID: | IL2_HUMAN |
Sample Type: | serum, plasma and cell culture supernates |
Description
Tissue Specificity | |
Post Translational Modifications | |
Function | Cytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer (NK) cells that plays pivotal roles in the immune response and tolerance. Binds to a receptor complex composed of either the high-affinity trimeric IL-2R (IL2RA/CD25, IL2RB/CD122 and IL2RG/CD132) or the low-affinity dimeric IL-2R (IL2RB and IL2RG). Interaction with the receptor leads to oligomerization and conformation changes in the IL-2R subunits resulting in downstream signaling starting with phosphorylation of JAK1 and JAK3. In turn, JAK1 and JAK3 phosphorylate the receptor to form a docking site leading to the phosphorylation of several substrates including STAT5. This process leads to activation of several pathways including STAT, phosphoinositide-3-kinase/PI3K and mitogen-activated protein kinase/MAPK pathways. Functions as a T-cell growth factor and can increase NK-cell cytolytic activity as well. Promotes strong proliferation of activated B-cells and subsequently immunoglobulin production. Plays a pivotal role in regulating the adaptive immune system by controlling the survival and proliferation of regulatory T-cells, which are required for the maintenance of immune tolerance. Moreover, participates in the differentiation and homeostasis of effector T-cell subsets, including Th1, Th2, Th17 as well as memory CD8-positive T-cells. |
Protein Name | Interleukin-2Il-2T-Cell Growth FactorTcgfAldesleukin |
Database Links | Reactome: R-HSA-5673001Reactome: R-HSA-8877330Reactome: R-HSA-9020558Reactome: R-HSA-912526 |
Cellular Localisation | Secreted |
Alternative ELISA Names | Interleukin-2 ELISA kitIl-2 ELISA kitT-Cell Growth Factor ELISA kitTcgf ELISA kitAldesleukin ELISA kitIL2 ELISA kit |
output |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance