Ficolin 2/Ficolin B Polyclonal Antibody, APC-Cy7 Conjugated
Cat# bs-13162R-APC-Cy7
Size : 100ul
Brand : Bioss
Ficolin 2/Ficolin B Polyclonal Antibody, APC-Cy7 Conjugated
Applications
Reactivity
Predicted Reactivity
Overview | |
Catalog # | bs-13162R-APC-Cy7 |
Product Name | Ficolin 2/Ficolin B Polyclonal Antibody, APC-Cy7 Conjugated |
Applications | WB, IF(IHC-P), IF(IHC-F), IF(ICC) |
Reactivity | Human |
Predicted Reactivity | Mouse, Rat |
Specifications | |
Conjugation | APC-Cy7 |
Host | Rabbit |
Source | KLH conjugated synthetic peptide derived from human Ficolin 2/Ficolin B |
Immunogen Range | 231-313/313 |
Clonality | Polyclonal |
Isotype | IgG |
Concentration | 1ug/ul |
Purification | Purified by Protein A. |
Storage Buffer | Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
Storage Condition | Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
Target | |
Gene ID | 2220 |
Subcellular location | Secreted |
Synonyms | 37 kDa elastin-binding protein; Collagen/fibrinogen domain containing protein 2; Collagen/fibrinogen domain-containing protein 2; EBP 37; EBP-37; EBP37; FCN 2; Fcn2; FCN2_HUMAN; FCNL; Ficolin collagen/fibrinogen domain containing lectin 2 hucolin; Ficolin B; Ficolin beta; Ficolin-2; Ficolin-B; Ficolin-beta; Ficolin2; Hucolin; L ficolin; L-ficolin; OTTHUMP00000022518; P35; RP11 263F14.2; Serum lectin p35. |
Background | Ficolin B is the designation in mouse and rat of a protein also known as L-ficolin, ficolin-2, collagen/fibrinogen domain-containing protein 2, serum lectin p35, EBP-37 or hucolin. Ficolin B is a 313 amino acid member of the ficolin lectin family. It is a secreted innate immunity pattern recognition molecule expressed in liver and plasma that forms a disulfide-linked homopolymer. This extensive N-terminal disulfide bridge formation can lead to a functional dodecamer polypeptide. Ficolin B binds to DNA ligands expressed by late apoptotic and necrotic cells to increase attachment and engulfment. Variation in ficolin B concentrations amongst individuals is associated with polymorphisms in the promoter and structural portion of the FCN2 gene. In patients with Beht's disease (BD), there exists a significant difference in allele frequency for FCN2 gene single nucleotide polymorphisms (SNPs) within the -557 and -64 promoter sites within HLA-B51 positive and HLA-B51 negative subgroups. |
Application Dilution | |
WB | 1:300-5000 |
IF(IHC-P) | 1:50-200 |
IF(IHC-F) | 1:50-200 |
IF(ICC) | 1:50-200 |