Anti-UBR1 antibody (1260-1500) {FITC}

Clonality:	Polyclonal
Conjugation:	FITC
Isotype:	IgG
Purification:	Affinity Purified
Concentration:	0.68-0.70 µg/µl
Dilution Range:	WB: 1:500 DB: 1:4, 000 ELISA: 1:4, 000 IP: 1:150 IHC: 1:50-1:150
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	UBR1
Gene ID:	197131
Uniprot ID:	UBR1_HUMAN
Immunogen Region:	1260-1500
Immunogen:	Synthetic peptide taken within amino acid region 1260-1500 on human UBR1 protein.

Tissue Specificity	Broadly expressed, with highest levels in skeletal muscle, kidney and pancreas. Present in acinar cells of the pancreas (at protein level).
Function	E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. May be involved in pancreatic homeostasis. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth.
Protein Name	E3 Ubiquitin-Protein Ligase Ubr1 N-Recognin-1 Ring-Type E3 Ubiquitin Transferase Ubr1 Ubiquitin-Protein Ligase E3-Alpha-1 Ubiquitin-Protein Ligase E3-Alpha-I
Database Links	Reactome: R-HSA-983168
Cellular Localisation	Cytoplasm Cytosol
Alternative Antibody Names	Anti-E3 Ubiquitin-Protein Ligase Ubr1 antibody Anti-N-Recognin-1 antibody Anti-Ring-Type E3 Ubiquitin Transferase Ubr1 antibody Anti-Ubiquitin-Protein Ligase E3-Alpha-1 antibody Anti-Ubiquitin-Protein Ligase E3-Alpha-I antibody Anti-UBR1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance