Anti-CAPRIN1 antibody (200-250) {FITC}

Clonality:	Polyclonal
Conjugation:	FITC
Isotype:	IgG
Purification:	Affinity Purified
Concentration:	0.54 µg/µl
Dilution Range:	WB: 1:500 DB: 1:10, 000 ELISA: 1:10, 000
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	CAPRIN1
Gene ID:	4076
Uniprot ID:	CAPR1_HUMAN
Immunogen Region:	200-250
Immunogen:	Synthetic peptide taken within amino acid region 200-250 on human Caprin 1 protein.

Tissue Specificity	Ubiquitous.
Post Translational Modifications	Tyrosine phosphorylation by EPHA4 promotes interaction with FMR1 and liquid-liquid phase separation (LLPS) for the formation of a membraneless compartment that concentrates mRNAs with associated regulatory factors. O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner. O-glycosylation by OGT inhibit ability to undergo liquid-liquid phase separation (LLPS).
Function	mRNA-binding protein that acts as a regulator of mRNAs transport, translation and/or stability, and which is involved in synaptic plasticity in neurons and cell proliferation and migration in multiple cell types. Acts as an mRNA regulator by mediating formation of some phase-separated membraneless compartment: undergoes liquid-liquid phase separation upon binding to target mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors. Undergoes liquid-liquid phase separation following phosphorylation and interaction with FMR1, promoting formation of cytoplasmic ribonucleoprotein granules that concentrate mRNAs with factors that inhibit translation and mediate deadenylation of target mRNAs. In these cytoplasmic ribonucleoprotein granules, CAPRIN1 mediates recruitment of CNOT7 deadenylase, leading to mRNA deadenylation and degradation. Binds directly and selectively to MYC and CCND2 mRNAs. In neuronal cells, directly binds to several mRNAs associated with RNA granules, including BDNF, CAMK2A, CREB1, MAP2, NTRK2 mRNAs, as well as to GRIN1 and KPNB1 mRNAs, but not to rRNAs.
Protein Name	Caprin-1 Cell Cycle-Associated Protein 1 Cytoplasmic Activation- And Proliferation-Associated Protein 1 Gpi-Anchored Membrane Protein 1 Gpi-Anchored Protein P137 Gpi-P137 P137gpi Membrane Component Chromosome 11 Surface Marker 1 Rna Granule Protein 105
Cellular Localisation	Cytoplasm Cytoplasmic Ribonucleoprotein Granule Cytosol Cell Projection Dendrite Lamellipodium Mediates Formation And Localizes To Cytoplasmic Ribonucleoprotein Membraneless Compartments Associated With Rna Granules At The Leading Edge Of Migrating Fibroblasts Colocalizes With Ddx3x
Alternative Antibody Names	Anti-Caprin-1 antibody Anti-Cell Cycle-Associated Protein 1 antibody Anti-Cytoplasmic Activation- And Proliferation-Associated Protein 1 antibody Anti-Gpi-Anchored Membrane Protein 1 antibody Anti-Gpi-Anchored Protein P137 antibody Anti-Gpi-P137 antibody Anti-P137gpi antibody Anti-Membrane Component Chromosome 11 Surface Marker 1 antibody Anti-Rna Granule Protein 105 antibody Anti-CAPRIN1 antibody Anti-GPIAP1 antibody Anti-GPIP137 antibody Anti-M11S1 antibody Anti-RNG105 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance