General Info
| Host: | Rabbit |
| Applications: | ELISA/IP/WB |
| Reactivity: | Bovine/Human/Mouse/Rat/Sheep |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-AQP7 (150-200) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Biotin |
| Isotype: | IgG |
| Purification: | Affinity Purified |
| Concentration: | 0.55-0.58 µg/µl |
| Dilution Range: | WB: 1:500ELISA: 1:10, 000IP: 1:200 |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Information
| Gene Symbol: | Aqp7 |
| Gene ID: | 11832 |
| Uniprot ID: | AQP7_MOUSE |
| Immunogen Region: | 150-200 |
| Immunogen: | Synthetic amidated peptide taken within amino acid region 150-200 on rat Aquaporin 7 protein, covalently modified and conjugated to KLH. |
Description
| Tissue Specificity | Detected in proximal tubules in kidney. Detected in the capillary network between muscle fibers in skeletal muscle and heart, and in spermatids and on spermatozoa tails in testis and epididymis. Detected in white and brown adipose tissue, especially on small blood vessels (at protein level). Detected in kidney and white adipose tissue. |
| Function | Forms a channel that mediates water and glycerol transport across cell membranes at neutral pH. The channel is also permeable to urea. Plays an important role in body energy homeostasis under conditions that promote lipid catabolism, giving rise to glycerol and free fatty acids. Mediates glycerol export from adipocytes. After release into the blood stream, glycerol is used for gluconeogenesis in the liver to maintain normal blood glucose levels and prevent fasting hypoglycemia. Required for normal glycerol reabsorption in the kidney. |
| Protein Name | Aquaporin-7Aqp-7Aquaglyceroporin-7 |
| Database Links | Reactome: R-MMU-432030Reactome: -MMU-432047 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCytoplasmCell CortexCytoplasmic Vesicle MembraneLipid DropletInternalized From The Cell Membrane In Response To Catecholamine-Induced Activation Of PkaDetected On Intracellular Membranes And Colocalizes With Lipid DropletsColocalizes With Plin1 In AdipocytesProbably On Lipid Droplets |
| Alternative Antibody Names | Anti-Aquaporin-7 antibodyAnti-Aqp-7 antibodyAnti-Aquaglyceroporin-7 antibodyAnti-Aqp7 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance