Anti-EIF2AK4 antibody (1600-1700) {Biotin}

Clonality:	Polyclonal
Conjugation:	Biotin
Isotype:	IgY
Purification:	Affinity Purified
Concentration:	0.58 µg/µl
Dilution Range:	WB: 1:500 DB: 1:10, 000 ELISA: 1:10, 000 IP: 1:200 IHC: 1:100 ICC: 1:100 IF: 1:100 CFM: 1:100
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	EIF2AK4
Gene ID:	440275
Uniprot ID:	E2AK4_HUMAN
Immunogen Region:	1600-1700
Immunogen:	Synthetic peptide taken within amino acid region 1600-1700 on human GCN2 protein.

Tissue Specificity	Widely expressed. Expressed in lung, smooth muscle cells and macrophages.
Post Translational Modifications	Autophosphorylated.autophosphorylation on Thr-899 is increased upon amino acid starvation and in UV irradiation cells and inhibited in presence of IMPACT.
Function	Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to low amino acid availability. Plays a role as an activator of the integrated stress response (ISR) required for adaptation to amino acid starvation. EIF2S1/eIF-2-alpha phosphorylation in response to stress converts EIF2S1/eIF-2-alpha into a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, and thus to a reduced overall utilization of amino acids, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion. Binds uncharged tRNAs. Required for the translational induction of protein kinase PRKCH following amino acid starvation. Involved in cell cycle arrest by promoting cyclin D1 mRNA translation repression after the unfolded protein response pathway (UPR) activation or cell cycle inhibitor CDKN1A/p21 mRNA translation activation in response to amino acid deprivation. Plays a role in the consolidation of synaptic plasticity, learning as well as formation of long-term memory. Plays a role in neurite outgrowth inhibition. Plays a proapoptotic role in response to glucose deprivation. Promotes global cellular protein synthesis repression in response to UV irradiation independently of the stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) and p38 MAPK signaling pathways. Plays a role in the antiviral response against alphavirus infection.impairs early viral mRNA translation of the incoming genomic virus RNA, thus preventing alphavirus replication. (Microbial infection) Plays a role in modulating the adaptive immune response to yellow fever virus infection.promotes dendritic cells to initiate autophagy and antigene presentation to both CD4(+) and CD8(+) T-cells under amino acid starvation.
Protein Name	Eif-2-Alpha Kinase Gcn2 Eukaryotic Translation Initiation Factor 2-Alpha Kinase 4 Gcn2-Like Protein
Database Links	Reactome: R-HSA-9633012
Cellular Localisation	Cytoplasm
Alternative Antibody Names	Anti-Eif-2-Alpha Kinase Gcn2 antibody Anti-Eukaryotic Translation Initiation Factor 2-Alpha Kinase 4 antibody Anti-Gcn2-Like Protein antibody Anti-EIF2AK4 antibody Anti-GCN2 antibody Anti-KIAA1338 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance