STRO-1 mouse monoclonal antibody, clone STRO-1, PE
Specifications
Product Data
Clone Name
STRO-1
Application
FC
Recommended Dilution
Flow cytometry.
Reactivity
Human
Antibody Host
Mouse
Isotype
IgM
Clonality
Monoclonal
Immunogen
Human CD34 positive bone marrow cells
Specificity
This antibody recognizes the cell surface antigen STRO-1 expressed by bone marrow mesenchymal stromal cells and nucleated erythroid precursors, but not by committed hematopoietic progenitors.
Buffer
Tris buffered saline (TBS) Label: PE State: Liquid purified Ig fraction Stabilizer: 0.2% (w/v) high-grade protease free Bovine Serum Albumin (BSA) Preservative: 15 mM sodium azide Label: Conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography.
Concentration
lot specific
Conjugation
PE
Storage
Store the antibody at 2-8°C. DO NOT FREEZE! This product is photosensitive and should be protected from light.
Stability
Shelf life: one year from despatch.
Shipping
Blue Ice
Background
STRO-1 is a cell surface antigen expressed by stromal elements in human bone marrow, identified by monoclonal antibody STRO-1. Approximately 10% of mononuclear cells, greater than 95% of which are nucleated erythroid precursors, are STRO-1 positive, whereas the CFU-GM (colony-forming unit granulocyte-macrophage), BFU-E (erythroid burst) and CFU-Mix (mixed colonies) committed progenitor cells are negative. CFU-F (fibroblast colony-forming cells) are present exclusively in the STRO-1 positive population. When plated under long-term bone marrow culture conditions, STRO-1 positive cells generate adherent cell layers containing multiple stromal cell types, including adipocytes, smooth muscle cells, osteoblasts, chondrocytes, and fibroblastic elements. In combination with glycophorin A, STRO-1 is a useful marker for identification of mesenchymal stem cells. STRO-1 and CD117 are markers for osteosarcoma cells.
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
