STRO-1 mouse monoclonal antibody, clone STRO-1, PE
Référence AM26067RP-N
Conditionnement : 100ug
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STRO-1 Mouse Monoclonal Antibody [Clone ID: STRO-1]
| Product Data | |
| Clone Name | STRO-1 |
|---|---|
| Application | FC |
| Recommended Dilution | Flow cytometry. |
| Reactivity | Human |
| Antibody Host | Mouse |
| Isotype | IgM |
| Clonality | Monoclonal |
| Immunogen | Human CD34 positive bone marrow cells |
| Specificity | This antibody recognizes the cell surface antigen STRO-1 expressed by bone marrow mesenchymal stromal cells and nucleated erythroid precursors, but not by committed hematopoietic progenitors. |
| Buffer | Tris buffered saline (TBS) Label: PE State: Liquid purified Ig fraction Stabilizer: 0.2% (w/v) high-grade protease free Bovine Serum Albumin (BSA) Preservative: 15 mM sodium azide Label: Conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography. |
| Concentration | lot specific |
| Conjugation | PE |
| Storage | Store the antibody at 2-8°C. DO NOT FREEZE! This product is photosensitive and should be protected from light. |
| Stability | Shelf life: one year from despatch. |
| Background | STRO-1 is a cell surface antigen expressed by stromal elements in human bone marrow, identified by monoclonal antibody STRO-1. Approximately 10% of mononuclear cells, greater than 95% of which are nucleated erythroid precursors, are STRO-1 positive, whereas the CFU-GM (colony-forming unit granulocyte-macrophage), BFU-E (erythroid burst) and CFU-Mix (mixed colonies) committed progenitor cells are negative. CFU-F (fibroblast colony-forming cells) are present exclusively in the STRO-1 positive population. When plated under long-term bone marrow culture conditions, STRO-1 positive cells generate adherent cell layers containing multiple stromal cell types, including adipocytes, smooth muscle cells, osteoblasts, chondrocytes, and fibroblastic elements. In combination with glycophorin A, STRO-1 is a useful marker for identification of mesenchymal stem cells. STRO-1 and CD117 are markers for osteosarcoma cells. |
| Reference Data | |