PD L1 (CD274) Mouse Monoclonal Antibody [Clone ID: J110]
CAT#: AM26478RP-N
PD L1 (CD274) mouse monoclonal antibody, clone J110, PE
Conjugation: FITC
Specifications
Product Data | |
Clone Name | J110 |
Applications | FC |
Recommended Dilution | Flow cytometry: 20 μl (ready for use). For details see protocol below. |
Reactivities | Human |
Host | Mouse |
Isotype | IgG1 |
Clonality | Monoclonal |
Immunogen | Fusion protein of the extracellular domain of human PD-1 and the constant region of human γ1 heavy chain |
Specificity | This antibody reacts with human PD-1. |
Formulation | PBS Label: PE State: Liquid Ig fraction Stabilizer: 1% BSA Preservative: 0.09% NaN3 |
Purification | Protein A agarose |
Conjugation | PE |
Storage | Store at 2-8 °C. |
Stability | Shelf life: one year from despatch. |
Gene Name | CD274 molecule |
Database Link | |
Background | Human PD-1 (programmed death-1) is a 55 kDa member of the immunoglobulin superfamily that is induced in cells undergoing apoptosis. The PD-1 protein contains an immunoreceptor tyrosine-based inhibitory motif and is expressed predominantly on activated T and B lymphocytes. PD-1 plays a key role in peripheral tolerance and autoimmune diseases and is thought to be involved in the maintenance of peripheral self-tolerance by serving as a negative regulator of immune responses. Two novel members of the B7 family have been identified as PD-1 ligands, PD-L1 (B7-H1) and PD-L2 (B7-DC). Evidence reported to date suggests overlapping functions for these two PD-1 ligands and their constitutive expression on some normal tissues and up-regulation on activated antigen presenting cells. |
Synonyms | PD-L1, PDCD1 ligand 1, B7H1, B7H1, B7 homolog 1, PDCD1L1, PDCD1LG1 |
Note | This product was originally produced by MBL International. Protocol: Flow cytometric analysis for floating cells |
Reference Data |
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