Omecamtiv mecarbil [873697-71-3]
Référence HY-14233-10mg
Conditionnement : 10mg
Marque : MedChemExpress
Description |
Omecamtiv mecarbil (CK-1827452) is a selective cardiac myosin activator. |
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In Vitro |
Omecamtiv mecarbil (10 μM) reduces the maximal ATPase (kcat) 4.5-fold and dramatically reduces the actin concentration at which ATPase is half-maximal (KATPase) 30-fold. The Omecamtiv mecarbil-induced inhibition of the actin-activated ATPase is evaluated in a concentration-dependent manner to determine the EC50 (0.52 ± 0.10 μM). Omecamtiv mecarbil does not change the overall actin affinity. Omecamtiv mecarbil traps a population of myosin heads in a weak actin affinity state with slow product release. Omecamtiv mecarbil can reduce the actin sliding velocity more than 100-fold in the in vitro motility assay[3]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |