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> IDE1 (1DE 1, Inducer of Definitive Endoderm 1)

IDE1 (1DE 1, Inducer of Definitive Endoderm 1)

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Référence 366889-10mg

Conditionnement : 10mg

Marque : US Biological

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366889 IDE1 (1DE 1, Inducer of Definitive Endoderm 1)

Clone Type
Polyclonal
Grade
Highly Purified
Shipping Temp
Blue Ice
Storage Temp
-20°C

Synonyms:|1DE 1, Inducer of Definitive Endoderm 1||Chemical Name:|1-[2-[(2-carboxyphenyl)methylene]hydrazide]-heptanedioic acid ||Molecular Formula: |C15 H18 N2O5||Molecular Weight:|306.3||CAS Number: |1160927-48-9||Purity: |≥98%||Applications: |FA||Appearance: Crystalline solid||Description:|IDE1 activates the TGF-beta signaling pathway and induces definitive endoderm formation in human and mouse embryonic stem cells. It is also reported to increase the levels of Nodal expression, induce Smad2 phosphorylation and SOX17 expression.||Storage:|Soluble in organic solvents such as ethanol and DMSO. DMSO up to 80mM.

Applications
Purity: Highly Purified (~98%)|Concentration: Not determined |Form: Supplied as a crystalline solid. ||Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Form
Supplied as a crystalline solid.
Purity
Highly Purified (~98%)
References
1. Hoveizi, E., Nabiuni, M., Parivar, K., Ai, J., & Massumi, M. (2014). Definitive endoderm differentiation of human‐induced pluripotent stem cells using signaling molecules and IDE1 in three‐dimensional polymer scaffold. Journal of Biomedical Materials Research Part A, 102(11), 4027-4036. 2. Borowiak, M., Maehr, R., Chen, S., Chen, A. E., Tang, W., Fox, J. L., & Melton, D. A. (2009). Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells. Cell stem cell, 4(4), 348-358. 3. Aguayo-Mazzucato, C., & Bonner-Weir, S. (2010). Stem cell therapy for type 1 diabetes mellitus. Nature Reviews Endocrinology, 6(3), 139-148.