Human JNK2 (MAPK9) activation kit by CRISPRa
Référence GA103791
Conditionnement : 1kit
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Human JNK2 (MAPK9) activation kit by CRISPRa
SKU
GA103791
MAPK9 CRISPRa kit - CRISPR gene activation of human mitogen-activated protein kinase 9
2 Weeks*
| Product Data | |
| Format | 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug) |
|---|---|
| Target Symbol | MAPK9 |
| Locus ID | 5601 |
| Components | GA103791G1, JNK2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA103791G2, JNK2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA103791G3, JNK2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077 |
| Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc. |
| Reference Data | |
| RefSeq | NM_001135044, NM_001308244, NM_002752, NM_139068, NM_139069, NM_139070, NM_001364610, NM_001364607, NM_001364608, NM_001364609, NM_001364612, NM_001364613, NM_001364611 |
| UniProt ID | P45984 |
| Synonyms | JNK-55; JNK2; JNK2A; JNK2ALPHA; JNK2B; JNK2BETA; p54a; p54aSAPK; PRKM9; SAPK; SAPK1a |
| Summary | The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. Studies of this gene's mouse counterpart suggest a key role in T-cell differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Sep 2008] |
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| SDS |
| SKU | Description | Size | ||
|---|---|---|---|---|
| KN207608 | MAPK9 - human gene knockout kit via CRISPR, HDR mediated | 1 kit | | |
| KN207608BN | MAPK9 - human gene knockout kit via CRISPR, HDR mediated | 1 kit | | |
| KN207608LP | MAPK9 - human gene knockout kit via CRISPR, HDR mediated | 1 kit | | |
| KN207608RB | MAPK9 - human gene knockout kit via CRISPR, HDR mediated | 1 kit | | |
| KN407608 | MAPK9 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. | 1 kit | | |
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.