Human Ionotropic Glutamate receptor 2 (GRIA2) activation kit by CRISPRa
Référence GA101947
Conditionnement : 1kit
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Human Ionotropic Glutamate receptor 2 (GRIA2) activation kit by CRISPRa
SKU
GA101947
GRIA2 CRISPRa kit - CRISPR gene activation of human glutamate ionotropic receptor AMPA type subunit 2
2 Weeks*
| Product Data | |
| Format | 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug) |
|---|---|
| Target Symbol | GRIA2 |
| Locus ID | 2891 |
| Components | GA101947G1, Ionotropic Glutamate receptor 2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA101947G2, Ionotropic Glutamate receptor 2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA101947G3, Ionotropic Glutamate receptor 2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077 |
| Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc. |
| Reference Data | |
| RefSeq | NM_000826, NM_001083619, NM_001083620 |
| UniProt ID | P42262 |
| Synonyms | GluA2; GluR-K2; GLUR2; GLURB; HBGR2 |
| Summary | Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene. [provided by RefSeq, Jul 2008] |
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| SDS |
| SKU | Description | Size | ||
|---|---|---|---|---|
| KN412107 | GRIA2 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. | 1 kit | | |
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.