Human glucose 6 phosphatase, catalytic subunit (G6PC) activation kit by CRISPRa
Référence GA101686
Conditionnement : 1kit
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Human glucose 6 phosphatase, catalytic subunit (G6PC) activation kit by CRISPRa
SKU
GA101686
G6PC CRISPRa kit - CRISPR gene activation of human glucose-6-phosphatase catalytic subunit
2 Weeks*
| Product Data | |
| Format | 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug) |
|---|---|
| Target Symbol | G6PC1 |
| Locus ID | 2538 |
| Components | GA101686G1, glucose 6 phosphatase, catalytic subunit gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA101686G2, glucose 6 phosphatase, catalytic subunit gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA101686G3, glucose 6 phosphatase, catalytic subunit gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077 |
| Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc. |
| Reference Data | |
| RefSeq | NM_000151, NM_001270397 |
| UniProt ID | P35575 |
| Synonyms | G6PC1; G6PT; GSD1; GSD1a |
| Summary | Glucose-6-phosphatase (G6Pase) is a multi-subunit integral membrane protein of the endoplasmic reticulum that is composed of a catalytic subunit and transporters for G6P, inorganic phosphate, and glucose. This gene (G6PC) is one of the three glucose-6-phosphatase catalytic-subunit-encoding genes in human: G6PC, G6PC2 and G6PC3. Glucose-6-phosphatase catalyzes the hydrolysis of D-glucose 6-phosphate to D-glucose and orthophosphate and is a key enzyme in glucose homeostasis, functioning in gluconeogenesis and glycogenolysis. Mutations in this gene cause glycogen storage disease type I (GSD1). This disease, also known as von Gierke disease, is a metabolic disorder characterized by severe hypoglycemia associated with the accumulation of glycogen and fat in the liver and kidneys.[provided by RefSeq, Feb 2011] |
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| SDS |
| SKU | Description | Size | ||
|---|---|---|---|---|
| KN415623 | G6PC - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. | 1 kit | | |
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.