Human DARC (Duffy Blood Group Chemokine Receptor) Sandwich ELISA Kit

Storage Instruction:	Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	4.5 hrs

Gene Symbol:	ACKR1
Gene ID:	2532
Uniprot ID:	ACKR1_HUMAN
Sample Type:	serum, plasma, cell lysates or other biological fluids.

Tissue Specificity	Found in adult kidney, adult spleen, bone marrow and fetal liver. In particular, it is expressed along postcapillary venules throughout the body, except in the adult liver. Erythroid cells and postcapillary venule endothelium are the principle tissues expressing duffy. Fy(-A-B) individuals do not express duffy in the bone marrow, however they do, in postcapillary venule endothelium.
Post Translational Modifications
Function	Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1, TARC and also for the malaria parasites P.vivax and P.knowlesi. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes.when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels.
Protein Name	Atypical Chemokine Receptor 1 Duffy Antigen/Chemokine Receptor Fy Glycoprotein Gpfy Glycoprotein D Plasmodium Vivax Receptor Cd Antigen Cd234
Database Links	Reactome: R-HSA-375276
Cellular Localisation	Early Endosome Recycling Endosome Membrane Multi-Pass Membrane Protein Predominantly Localizes To Endocytic Vesicles And Upon Stimulation By The Ligand Is Internalized Via Caveolae Once Internalized The Ligand Dissociates From The Receptor And Is Targeted To Degradation While The Receptor Is Recycled Back To The Cell Membrane
Alternative ELISA Names	Atypical Chemokine Receptor 1 ELISA kit Duffy Antigen/Chemokine Receptor ELISA kit Fy Glycoprotein ELISA kit Gpfy ELISA kit Glycoprotein D ELISA kit Plasmodium Vivax Receptor ELISA kit Cd Antigen Cd234 ELISA kit ACKR1 ELISA kit DARC ELISA kit FY ELISA kit GPD ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance