Human Aconitase 1 (ACO1) activation kit by CRISPRa
Référence GA100036
Conditionnement : 1kit
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Human Aconitase 1 (ACO1) activation kit by CRISPRa
SKU
GA100036
ACO1 CRISPRa kit - CRISPR gene activation of human aconitase 1
2 Weeks*
| Product Data | |
| Format | 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug) |
|---|---|
| Target Symbol | ACO1 |
| Locus ID | 48 |
| Components | GA100036G1, Aconitase 1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA100036G2, Aconitase 1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA100036G3, Aconitase 1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077 |
| Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc. |
| Reference Data | |
| RefSeq | NM_001278352, NM_002197, NM_001362840 |
| UniProt ID | P21399 |
| Synonyms | ACONS; HEL60; IREB1; IREBP; IREBP1; IRP1 |
| Summary | The protein encoded by this gene is a bifunctional, cytosolic protein that functions as an essential enzyme in the TCA cycle and interacts with mRNA to control the levels of iron inside cells. When cellular iron levels are high, this protein binds to a 4Fe-4S cluster and functions as an aconitase. Aconitases are iron-sulfur proteins that function to catalyze the conversion of citrate to isocitrate. When cellular iron levels are low, the protein binds to iron-responsive elements (IREs), which are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. When the protein binds to IRE, it results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degraded transferrin receptor mRNA. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alternative splicing results in multiple transcript variants [provided by RefSeq, Jan 2014] |
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| SDS |
| SKU | Description | Size | ||
|---|---|---|---|---|
| KN201857 | ACO1 - human gene knockout kit via CRISPR, HDR mediated | 1 kit | | |
| KN201857BN | ACO1 - human gene knockout kit via CRISPR, HDR mediated | 1 kit | | |
| KN201857LP | ACO1 - human gene knockout kit via CRISPR, HDR mediated | 1 kit | | |
| KN201857RB | ACO1 - human gene knockout kit via CRISPR, HDR mediated | 1 kit | | |
| KN401857 | ACO1 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. | 1 kit | | |
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.