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Réactifs et instruments pour l'immunologie, la biologie cellulaire et la biologie moléculaire.

Cd63 Mouse siRNA Oligo Duplex (Locus ID 12512)

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Référence SR406624

Conditionnement : 1kit

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Cd63 Mouse siRNA Oligo Duplex (Locus ID 12512)

SKU

SR406624

Cd63 (Mouse) - 3 unique 27mer siRNA duplexes - 2 nmol each

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Stability One year from date of shipment when stored at -20°C. # of transfections Approximately 330 transfections/2nmol in 24-well plate under optimized conditions (final conc. 10 nM). Note Single siRNA duplex (10nmol) can be ordered. Reference Data RefSeq NM_001042580, NM_001282966, NM_007653 UniProt ID P41731 Synonyms C75951; ME491; Tspan30 Summary Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli.[UniProtKB/Swiss-Prot Function] Performance Guaranteed OriGene guarantees that at least two of the three Dicer-Substrate duplexes in the kit will provide at least 70% or more knockdown of the target mRNA when used at 10 nM concentration by quantitative RT-PCR when the TYE-563 fluorescent transfection control duplex (cat# SR30002) indicates that >90% of the cells have been transfected and the HPRT positive control (cat# SR30003) provides 90% knockdown efficiency.

For non-conforming siRNA, requests for replacement product must be made within ninety (90) days from the date of delivery of the siRNA kit. To arrange for a free replacement with newly designed duplexes, please contact Technical Services at tech@biovalley.fr. Please provide your data indicating the transfection efficiency and measurement of gene expression knockdown compared to the scrambled siRNA control (quantitative RT-PCR data required).