CD134 Human, IgG2a Fc Mouse, Fusion Protein (OX40)

Human CD134 (OX40) (ACT35) is an activation-associated antigen which is predominantly expressed on activated CD4 positive cells. CD134 antigen is a member of the tumor necrosis factor (TNF) receptor family of molecules and may be involved with regulating T cell-dependent B cell proliferation and differentiation (2).||The CD134 costimulatory pathway seems to be more effective for costimulation of CD4+ helper T cells than for CD8+ effector T cells (5). Blockade of this interaction in mouse abrogated immunological effects in several models of immflamation and rejection (6,7,8,9). CD134-muIg fusion protein binds to CD134L on Human Umbilical Cord Endothelial Cells (HUVEC).||Human CD134(OX40)-muIg Fusion Protein*||Molecular Structure: |A soluble molecule consisting of the extracellular (185 aa) domain of human CD134 fused to the murine IgG2a Fc (232 aa). Predicted monomeric non-glysylated weight is 45.6kD. Fusion construct is dimeric and runs about 105kD in non-reduced SDS-PAGE.||Applications: |Suitable for use in ELISA, Flow Cytometry. CD134-muIg fusion protein blocks binding of anti-human CD134 to human tumor cells. Other applications not tested.||Recommended Dilution|Optimal dilutions to be determined by the researcher.||Storage and Stability:|May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. Aliquots are stable for 6 months after receipt. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.