Atezolizumab [1380723-44-3]

Référence HY-P9904-1mg

Conditionnement : 1mg

Marque : MedChemExpress

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Description

Atezolizumab (MPDL3280A) is a selective humanized monoclonal IgG1 antibody against programmed death ligand 1 (PD-L1), used for cancer research.

Isotype

Human IgG1 (N297A) kappa

Recommend Isotype Controls
Species

Humanized

In Vitro

Atezolizumab (0, 2.5, 5, 10, 20, and 40?μg/ml; 24 hours; HOS and 143B cells) inhibits proliferation and induces immune-independent apoptosis of osteosarcoma cells[1].
Atezolizumab impairs the function of mitochondria to cause the imbalance between oxidants and antioxidants. Atezolizumab induces mitochondria-related apoptosis of osteosarcoma cells by activating JNK pathway[1].
Atezolizumab (10 μg/ml; 24 hours; HOS and 143B cells) induces autophagy in osteosarcoma cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Format
  • Human IgG1 kappa
Biological Activity
  • Flow cytometry analysis of PD-L1 overexpression HEK293 cells labelling PD-L1 with Atezolizumab at 67nM (Red). Goat anti human IgG Fc (Alexa Fluor488) was used as the secondary antibody at 1/400 dilution. Isotype control - human IgG (Blue). Unlabeled control - Unlabelled cells (Gray).
Pureté et documentation
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