AKT1/2/3 (Ser472/Ser473/Ser474) Antibody, PE-Cy5 Conjugated
Référence bs-0876R-PE-Cy5
Conditionnement : 100ul
Marque : Bioss
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AKT1/2/3 (Ser472/Ser473/Ser474) Antibody, PE-Cy5 Conjugated
Applications
Reactivity
Predicted Reactivity
| Overview | |
| Catalog # | bs-0876R-PE-Cy5 |
| Product Name | AKT1/2/3 (Ser472/Ser473/Ser474) Antibody, PE-Cy5 Conjugated |
| Applications | WB |
| Reactivity | Human, Mouse, Rat, Bovine, Chicken, Rabbit, Fish, Others |
| Predicted Reactivity | Dog, Cow, Sheep |
| Specifications | |
| Conjugation | PE-Cy5 |
| Host | Rabbit |
| Source | KLH conjugated synthetic phosphopeptide derived from human AKT1 around the phosphorylation site of Ser473 |
| Modification Site | Ser473 |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1ug/ul |
| Purification | Purified by Protein A. |
| Storage Buffer | Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Storage Condition | Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
| Target | |
| Gene ID | 24185 |
| Swiss Prot | P47196 |
| Subcellular location | Cytoplasm, Nucleus, Cell membrane |
| Synonyms | Akt; RAC-alpha serine/threonine-protein kinase; Protein kinase B; PKB; Protein kinase B alpha; PKB alpha; RAC-PK-alpha; Akt1 |
| Background | AKT1-specific substrates have been recently identified, including palladin (PALLD), which phosphorylation modulates cytoskeletal organization and cell motility; prohibitin (PHB), playing an important role in cell metabolism and proliferation; and CDKN1A, for which phosphorylation at 'Thr-145' induces its release from CDK2 and cytoplasmic relocalization. These recent findings indicate that the AKT1 isoform has a more specific role in cell motility and proliferation. Phosphorylates CLK2 thereby controlling cell survival to ionizing radiation. |
| Application Dilution | |
| WB | 1:300-5000 |