ADAMTS5 Recombinant Protein
Référence OPCD01109-10UG
Conditionnement : 10ug
Marque : Aviva Systems Biology
Contactez votre distributeur local :
Téléphone : +1 850 650 7790
| Datasheets/Manuals | Printable datasheet for ADAMTS5 Recombinant Protein (OPCD01109) |
|---|
| Predicted Species Reactivity | Homo sapiens|Human |
|---|---|
| Product Format | Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose. |
| Host | E.coli |
| Conjugation | Unconjugated |
| Application | Ctrl (+), SDS-PAGE, WB |
| Additional Information | Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method) |
| :: | Residues: Glu485-Pro622 |
| :: | Subcellular Location: Secreted, extracellular space, extracellular matrix. |
| Reconstitution and Storage | 2°C to 8°C|-80°C |
| Concentration | 200 ug/mL (prior to lyoph) |
| Purity | > 95% |
| Source | E.coli |
| Tag | N-terminal His Tag |
| Gene Symbol | ADAMTS5 |
|---|---|
| Gene Full Name | ADAM metallopeptidase with thrombospondin type 1 motif 5 |
| Alias Symbols | a disintegrin and metalloproteinase with thrombospondin motifs 11;A disintegrin and metalloproteinase with thrombospondin motifs 5;a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2);ADAM-TS 11;ADAM-TS 5;ADAMTS11;ADAMTS-11;ADAMTS-5;ADAM-TS5;ADMP-2;aggrecanase-2. |
| NCBI Gene Id | 11096 |
| Protein Name | A disintegrin and metalloproteinase with thrombospondin motifs 5 |
| Description of Target | Metalloproteinase that plays an important role in connective tissue organization, development, inflammation, arthritis, and cell migration. ADAMTS5 is an extracellular matrix (ECM) degrading enzyme that show proteolytic activity toward the hyalectan group of chondroitin sulfate proteoglycans (CSPGs) including aggrecan, versican, brevican and neurocan (PubMed:16133547, PubMed:18992360). Cleavage within the hyalectans occurs at Glu-Xaa recognition motifs. Plays a role in embryonic development, including limb and cardiac morphogenesis, and skeletal muscle development through its versican remodeling properties. Participates in development of brown adipose tissue and browning of white adipose tissue. Plays an important role for T-lymphocyte migration from draining lymph nodes following viral infection. |
| Uniprot ID | Q9UNA0 |
| Protein Accession # | NP_008969.2 |
| Nucleotide Accession # | NM_007038.4 |
| Protein Size (# AA) | Glu485~Pro622 |
| Molecular Weight | 19kDa |